Scientific Research

César Milstein: Hybridoma Cells to Create Monoclonal Antibodies

by David Warmflash, MD

Classics

An amino acid sequence in the active centre of phosphoglucomutase

Milstein, C., & Sanger, F. (1961). An amino acid sequence in the active centre of phosphoglucomutase. Biochemical Journal, 79(3), 456–469.

Origin of antibody variation

Brenner, S. and Milstein, C. (1966). Origin of antibody variation. Nature, 211: 242-243.

From the structure of antibodies to the diversification of the immune response

Milstein, C. (1985). From the structure of antibodies to the diversification of the immune response. EMBO Journal, 4(5) 1083-1092.

News & Events

University of Iowa-based cell bank a go-to source for researchers

A news article about the Developmental Studies Hybridoma Bank (DSHB) holds 3,000+ hybridomas and tens of thousands of samples of the antibodies they produce.

Research

Google Scholar

Google - Research database allows searching of the scholarly literature.

Experiment!

How do monoclonal antibodies work?

Created by Roche and Mark Jones, this interactive describes the various functions of antibodies.

Next Generation Science Standards (NGSS)

Next Generation Science Standards: For States, By States

National Academies Press: A Framework for K-12 Science Education

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